RNA interference – Communicable Diseases Research

Folic acid: a potential inhibitor against SARS-CoV-2 nucleocapsid protein

엽산: SARS-CoV-2 뉴클레오캡시드 단백질에 대한 잠재적 억제제

Article

Published on 2022-12-012022-09-11
Journal: Pharmaceutical Biology
[Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료법,

[키워드] analysed Analysis antagonist antiviral effects antivirus association cellular Chinese Chinese medicine Compound Concentration coronavirus disease Coronavirus disease 2019 COVID-19 Data analysis docking drug target experiment Folic acid Genes global pandemic Host hub genes identify inhibit inhibition inhibitor involved material mCherry mCherry expression mechanism molecular molecular docking network pharmacology Network pharmacology. Nucleocapsid phosphoprotein Phosphoprotein Protein Regulatory RNA interference RNAi SARS-CoV-2 SARS-CoV-2 N SARS-CoV-2 nucleocapsid screened shown target targets therapeutic target Traditional Traditional Chinese medicine virus
[DOI] 10.1080/13880209.2022.2063341 PMC 바로가기 [Article Type] Article

Combination treatments including the small-interfering RNA JNJ-3989 induce rapid and sometimes prolonged viral responses in patients with CHB

Clinical Trial

Published on 2022-11-012023-06-13
Journal: Journal of hepatology
[Category] B형 간염,

[키워드] antiviral therapy Chronic Hepatitis B Hepatitis B surface antigen. Hepatitis B virus JNJ-3989 RNA interference
[DOI] 10.1016/j.jhep.2022.07.010 PMC 바로가기 [Article Type] Clinical Trial

New strategies for the treatment of chronic hepatitis B

Review

Published on 2022-09-012023-06-12
Journal: Trends in molecular medicine
[Category] B형 간염,

[키워드] cccDNA functional cure gene editing Hepatitis B virus. RNA interference
[DOI] 10.1016/j.molmed.2022.06.002 PMC 바로가기 [Article Type] Review

Development and application of ribonucleic acid therapy strategies against COVID-19

Review

Published on 2022-08-012023-08-30
Journal: International Journal of Biological Sciences
[Category] E형 간염,

[키워드] Antisense oligonucleotides COVID-19 ribonucleic acid therapy ribozymes. RNA interference SARS-CoV-2
[DOI] 10.7150/ijbs.72706 PMC 바로가기 [Article Type] Review

RNA solutions to treat inborn errors of metabolism

신진대사의 선천적 오류를 치료하기 위한 RNA 솔루션

Review

Published on 2022-08-012022-09-11
Journal: Molecular genetics and metabolism
[Category] 유전자 메커니즘,

Expanding RNAi therapeutics to extrahepatic tissues with lipophilic conjugates

Research

Published on 2022-06-022022-10-05
Journal: Nature biotechnology
[Category] Coronavirus, 진단,

Computational study and design of effective siRNAs to silence structural proteins associated genes of Indian SARS-CoV-2 strains

인도 SARS-CoV-2 균주의 구조 단백질 관련 유전자를 침묵시키는 효과적인 siRNA의 계산 연구 및 설계

Article

Published on 2022-06-012022-09-11
Journal: Computational biology and chemistry
[Category] COVID19(2023년), SARS, 치료법, 치료제,

[키워드] absence acute respiratory disease Ago2 Algorithm animal models antiviral drug antiviral drugs Antiviral treatment binding candidate collected complementary Consensus COVID-19 deaths docking Effect effective envelope protein feature free energy GC content gene silencing Genes Genome Health Organization heat capacity Human Human genome in vitro in vivo India melting temperature membrane protein molecular docking analysis nucleic acid nucleocapsid nucleotide nucleotides outbreak pandemic parameter pathogenic coronavirus pathway Post-transcriptional gene silencing Protein public health Region reported Respiratory disease RNA RNA interference RNAi SARS-CoV-2 SARS-CoV-2 strain SARS-CoV-2 strains selected sequence sequenced siRNA siRNA molecule siRNA molecules siRNA. siRNAs structural protein structural proteins Surface glycoprotein target target gene target mRNA temperature Therapeutic treatment triggered viral pathogenesis WHO World Health Organization
[DOI] 10.1016/j.compbiolchem.2022.107687 PMC 바로가기 [Article Type] Article

Discovery and Use of Long dsRNA Mediated RNA Interference to Stimulate Antiviral Protection in Interferon Competent Mammalian Cells

인터페론 유능한 포유동물 세포에서 항바이러스 보호를 자극하기 위한 긴 dsRNA 매개 RNA 간섭의 발견 및 사용

Article

Published on 2022-05-062022-09-11
Journal: Frontiers in Immunology
[Category] COVID19(2023년), SARS, 치료법, 치료제,

[키워드] Antiviral Antiviral effect antiviral response antiviral responses cell line cells cellular cleaved comparable competent complementary Concentration cornerstone CoV dependent on Dicer dsRNA Evidence explanation expressing fluorescent functional gene targeting generate green fluorescent protein HCoV HCoV-229E human coronavirus human coronaviruses IFN immune defense induce inducer inhibit Interference interferons knockdown Lineage Long long dsRNA mammalian mammalian cell mammalian cells Mediated mRNA pathway platform preventing infection produced protection Protein provide required responsible retained RISC RNA RNA interference RNA-induced silencing complex RNAi RNAi pathway SARS-CoV-2 replication sequence shown significantly siRNA siRNAs stimulate stomatitis suppress therapeutic These cells threshold type I interferon vesicular stomatitis vesicular stomatitis virus viral inhibition. virus VSV-GFP
[DOI] 10.3389/fimmu.2022.859749 PMC 바로가기 [Article Type] Article

Improving siRNA design targeting nucleoprotein gene as antiviral against the Indonesian H5N1 virus

Article

Published on 2022-03-012023-06-22
Journal: Journal of veterinary science
[Category] 조류인플루엔자,

[키워드] Antiviral agents H5N1 subtype Indonesia Influenza in birds. RNA interference
[DOI] 10.4142/jvs.21174 PMC 바로가기

Inhibition of Protein N- Glycosylation Blocks SARS-CoV-2 Infection

Research Article

Published on 2022-02-152022-10-29
Journal: mBio
[Category] COVID-19, MERS,